Introduction: Anti-inflammatory Treatment of Childhood Asthma: Cromoglycate and Nedocromil as Non-steroidal Alternatives?
نویسنده
چکیده
منابع مشابه
Cromoglycate and Nedocromil: Influence on Airway Reactivity
Although basic mechanisms of bronchial hyper-responsiveness (BHR) are still incompletely understood, inflammation of airways is likely to play a fundamental role in modulating BHR in patients with asthma. The involvement of several inflammatory cells (eosinophils, mast cells, lymphocytes, neutrophils, macrophages and platelets) and of bioactive mediators secreted by these cells in the pathogene...
متن کاملReport of a workshop assessing the risks and benefits of inhaled anti-inflammatory treatment for asthma.
The causes of asthma remain unknown although it is now clear that the underlying pathology of the disease, even in its mildest forms, is one of chronic persistent inflammation. This fact is recognised in many national, and more recently, international guidelines, which recommend that treatment in all but the most mild episodic asthma should be aimed at the underlying pathology rather than at su...
متن کاملEffects of nedocromil sodium in the treatment of non-allergic subjects with chronic obstructive pulmonary disease.
BACKGROUND Nedocromil sodium, a nonsteroidal anti-inflammatory drug, is effective in the treatment of asthma. Its efficacy in the treatment of chronic obstructive pulmonary disease (COPD) has not been investigated. METHODS Fifty four non-allergic patients with COPD were randomised to 10 weeks of treatment with placebo or nedocromil sodium (4 x 8 mg/day) in a double blind study. RESULTS Nedo...
متن کاملCromoglycate and nedocromil enhanced the reactive oxygen species-dependent suppressions with, but not without, dexamethasone in ischaemic and histamine paw oedema of mice
Anti-inflammatory actions of two anti-allergic drugs, alone or with dexamethasone (Dex) were examined in two models, because inflammation is claimed to be important for allergic events, especially for asthma. Cromoglycate and nedocromil were tested in ischaemic- and histamineinduced paw oedema models of mice. These antiallergic drugs (1-100 mg/kg, i.p.) failed to suppress these oedemata, but en...
متن کاملA double blind placebo controlled group comparative study of ophthalmic sodium cromoglycate and nedocromil sodium in the treatment of vernal keratoconjunctivitis.
In a 4 week double masked comparative study, patients received 2% nedocromil sodium (48), 2% sodium cromoglycate (48), or placebo eye drops (42), four times daily, for the treatment of vernal keratoconjunctivitis (VKC). Clinical examinations of eye condition and symptom severity were made before and after a 1 week baseline before starting test treatment, and after 1, 2, and 4 weeks of treatment...
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ورودعنوان ژورنال:
- Mediators of Inflammation
دوره 3 شماره
صفحات -
تاریخ انتشار 1994